Dr. Richard Fehn
B.S., California State College, San Bernardino
Dr. Rich Fehn, longtime professor in the Biology Department at CSUSB, passed away June 30, 2007 after a long battle with cancer. Professor Fehn served the department as an outstanding leader, teacher, and scientist for twenty-four years. He was a past Chair of the department, a Golden Apple award winner for excellence in teaching, and was named the Outstanding Professor at CSUSB in 2004. His legacy includes a generation of students who were inspired by his teaching in both the classroom and the research lab.
My laboratory engages pre-professional undergraduate and Masters-level graduate students in studies that focus primarily on elucidating the regulatory mechanisms for, and actions of, thyroid hormones in association with obesity and noninsulin-dependent diabetes mellitus (NIDDM). The diabetes (db or lep) and obese (ob or lepr) mouse models have been used to study thyroid dysregulation, the role of leptin in thyroid regulation, leptin-thyroid hormone interactions in feeding, glucose disposal, lipid metabolism and glucose transporter trafficking, as well as interactions with the sympathetic nervous system. Collectively, these factors determine the tissue distributions and utilization of metabolic substrates that, in turn, affect myocellular insulin-sensitivity, hepatic glucose production, and total body energy expenditures, all of which are central to the obese-diabetic syndrome. This work employs in vivo metabolic studies in combination with ultrastructural and molecular analyses to provide an integrated multi-level view of the pathology.
Representative Publications and Presentations:
Reno, C. and R. Fehn, 2007. Leptin and Thyroid Hormone Regulate Hepatic Lipid Trafficking into Macro- and Microvesicular Pools. The FASEB Journal 21:683.2.
Jun, L. and R. Fehn, 2006. High-fat diet induced insulin resistance is more robust and reliable in Wistar than Sprague-Dawley Rats, Experimental Biology 2006, San Francisco, CA A2096.
Jun, L. and R. Fehn. 2006. Independent and Interactive Effects of Insulin and Thyroid Hormone on Soleus Muscle GLUT4 Transporter Trafficking in Fed and Fasted Diet-Induced Obese-Diabetic Rats, Annual Meeting of the American Diabetes Association, 66th Scientific Sessions, Washington, D.C. June 2006. A2005-PO
Jun, L., E. Anderson, J. An, C. Clark, C. Newgard, R. Fehn. 2004. Persistent insulin-stimulated GLUT4 trafficking despite high-fat induced intramyocellular lipids. Experimental Biology 2004, Washington D.C. (A787.18).
Fehn, R, C. Dunn, L. Jun, E. Anderson, S. Marshall 2003. Lipid utilization is induced and feeding inhibited by adenovirus-mediated gene delivery using nembutal and cyclosporine. Experimental Biology 2004, Washington D.C. (A102.14).
Jun, L. and R. Fehn 2003 Short-term increase in intramyocellular lipid content supports enhanced lipid oxidation without compromising serum glycemic status. FASEB J. 17(4):A275, 177.5.
Fehn, R. and R. Moussa 2002 Peripheral Sympathetic Ablation Prevents Leptin-induced Thyroid Stimulation in Obese B6.V Lepob Mice. FASEB J. 16(4):A786, 616.18.
Fehn, R., R. Moussa, and J. Donkor 2002 Dyslipidemia in Obese Mice: Regulation by Leptin and Thyroid Hormone Following Peripheral Sympathetic Neural Ablation. FASEB J. 16(4):A399, 361.4.
Fehn, R., R. Moussa, and J. Donkor 2002 Leptin & Thyroid Hormone in Metabolic Substrate Selection and Trafficking following Sympathetic Ablation. Diabetes 51(2):A581, 2407.
Fehn, R., C. Clark, J. Donkor, B. Underhill, and S. Meacham. 2001. Hepatic Glycogen Depletion and Microvesicular Steatosis in Leptin-deficient Obese Mice Administered Thyroid Hormone. Diabetes 50 (Suppl. 2): A327, 1360-P.
Fehn, R., C. Clark, B. Underhill, R. Moussa , J. Donkor. 2001. A Role for Leptin in Regulating Peripheral Thyroxine Monodeiodination. FASEB J. 15(4):A597 480.6.
Fehn, R. and C. Clark. 2000. Leptin and Thyroid Hormone in Lipid Trafficking: A Comparison in ob/ob and db/db Mice. FASEB J. 15(4):A736 511.6.
Urquidies, P., C. Clark, and R. Fehn. 2000. Hepatic GLUT2 Overexpression in db/db Mice is Suppressed by T3-Induced Peripheral Fatty Acid Mobilization. FASEB J. 14(4):A204 150.5.
Fehn, R., C. Clark, F. Galicia, and B. Underhill. 1999. Leptin Restores Metabolism by Correcting the Hypothyroid Status of ob/ob Mice. FASEB Journal 13(4):A343-264.5.
Clark, C. and R. Fehn. 1999. Thyroid Hormone Induces Fatty Liver in db/db Mice. FASEB Journal 13(4):A342-264.4.
Fehn, R., C. Clark, F. Galicia, and B. Underhill. 1999. Leptin Restores Metabolism by Correcting the Hypothyroid Status of ob/ob Mice, FASEB Journal 13(4):A343.
Clark, C. and R. Fehn. 1999. Thyroid Hormone Induces Fatty Liver in db/db Mice, FASEB Journal 13(4):A342.
Fehn, R., C. Clark, P. Estrada. 1998. Thyroid Hormone Restores Metabolism in Leptin-Resistant db Mice, FASEB Journal 12(4):A431.
BIOL 200 - Biology of the Cell
BIOL 424 - Animal Physiology
BIOL 576 - Endocrinology